L17F (p.Leu17Phe) variant of DCC (Netrin receptor DCC)
L17F (p.Leu17Phe) in DCC (Netrin receptor DCC) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
L17F (p.Leu17Phe) variant details
- p.Leu17Phe
- ExAC rs765345419
- TOPMed rs765345419
- gnomAD rs765345419
- Missense
- Variant Prioritization Score for Impact Estimate 0.335
- REVEL 0.16
- MetaLR 0.08
- MetaSVM -1.06
- CADD 23.50
- PolyPhen-2 0.00
- SIFT 0.15
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available