A25V (p.Ala25Val) variant of DCC (Netrin receptor DCC)
A25V (p.Ala25Val) in DCC (Netrin receptor DCC) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
A25V (p.Ala25Val) variant details
- p.Ala25Val
- rs548959522
- NCI-TCGA Cosmic COSV7143
- 1000Genomes rs548959522
- ExAC rs548959522
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.301
- REVEL 0.10
- MetaLR 0.06
- MetaSVM -1.05
- CADD 22.70
- PolyPhen-2 0.00
- SIFT 0.52
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available