A25T (p.Ala25Thr) variant of DCC (Netrin receptor DCC)
A25T (p.Ala25Thr) in DCC (Netrin receptor DCC) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
A25T (p.Ala25Thr) variant details
- p.Ala25Thr
- rs764708082
- NCI-TCGA Cosmic COSV7143
- ExAC rs764708082
- gnomAD rs764708082
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.276
- REVEL 0.09
- MetaLR 0.06
- MetaSVM -1.07
- CADD 22.90
- PolyPhen-2 0.01
- SIFT 0.43
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available