A25E (p.Ala25Glu) variant of DCC (Netrin receptor DCC)
A25E (p.Ala25Glu) in DCC (Netrin receptor DCC) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
A25E (p.Ala25Glu) variant details
- p.Ala25Glu
- 1000Genomes rs548959522
- ExAC rs548959522
- TOPMed rs548959522
- gnomAD rs548959522
- Missense
- Variant Prioritization Score for Impact Estimate 0.324
- REVEL 0.14
- MetaLR 0.06
- MetaSVM -1.06
- CADD 22.40
- PolyPhen-2 0.04
- SIFT 0.33
- Most common in the 1KG:GWD population (allele frequency 0.0043)
- Structural context available