W7L (p.Trp7Leu) variant of DBH (Dopamine beta-hydroxylase)
W7L (p.Trp7Leu) in DBH (Dopamine beta-hydroxylase) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
W7L (p.Trp7Leu) variant details
- p.Trp7Leu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.249
- REVEL 0.16
- MetaLR 0.05
- MetaSVM -1.05
- CADD 13.20
- PolyPhen-2 0.02
- SIFT 0.66
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available