H59Y (p.His59Tyr) variant of DAP3 (P51398)
H59Y (p.His59Tyr) in DAP3 (P51398) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
H59Y (p.His59Tyr) variant details
- p.His59Tyr
- rs759970366
- NCI-TCGA Cosmic COSV1005
- cosmic curated COSV10054
- ExAC rs759970366
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.414
- REVEL 0.30
- ESM-1b 0.00
- AlphaMissense 0.38
- CADD 24.60
- PolyPhen-2 0.95
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available