H35Y (p.His35Tyr) variant of DAP3 (P51398)
H35Y (p.His35Tyr) in DAP3 (P51398) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
H35Y (p.His35Tyr) variant details
- p.His35Tyr
- rs1365737302
- NCI-TCGA Cosmic COSV5802
- cosmic curated COSV58023
- gnomAD rs1365737302
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.162
- REVEL 0.06
- ESM-1b 0.00
- AlphaMissense 0.07
- CADD 16.60
- PolyPhen-2 0.09
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available