W58* (p.Trp58Ter) variant of CYP3A5 (Cytochrome P450 3A5)
W58* (p.Trp58Ter) in CYP3A5 (Cytochrome P450 3A5) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
W58* (p.Trp58Ter) variant details
- p.Trp58Ter
- NCI-TCGA Cosmic COSV5611
- cosmic curated COSV56118
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.496
- CADD 27.70
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available