T74M (p.Thr74Met) variant of CYP3A5 (Cytochrome P450 3A5)
T74M (p.Thr74Met) in CYP3A5 (Cytochrome P450 3A5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
T74M (p.Thr74Met) variant details
- p.Thr74Met
- TOPMed rs1257327336
- gnomAD rs1257327336
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.17
- CADD 15.20
- PolyPhen-2 0.02
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available