T74K (p.Thr74Lys) variant of CYP3A5 (Cytochrome P450 3A5)
T74K (p.Thr74Lys) in CYP3A5 (Cytochrome P450 3A5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
T74K (p.Thr74Lys) variant details
- p.Thr74Lys
- TOPMed rs1257327336
- gnomAD rs1257327336
- Missense
- Variant Prioritization Score for Impact Estimate 0.255
- REVEL 0.27
- CADD 21.10
- PolyPhen-2 0.17
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available