T29I (p.Thr29Ile) variant of CYP3A5 (Cytochrome P450 3A5)
T29I (p.Thr29Ile) in CYP3A5 (Cytochrome P450 3A5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
T29I (p.Thr29Ile) variant details
- p.Thr29Ile
- rs1401028894
- NCI-TCGA Cosmic COSV9976
- cosmic curated COSV99769
- gnomAD rs1401028894
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.219
- REVEL 0.08
- CADD 15.00
- PolyPhen-2 0.30
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available