R162W (p.Arg162Trp) variant of CYP3A5 (Cytochrome P450 3A5)
R162W (p.Arg162Trp) in CYP3A5 (Cytochrome P450 3A5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
R162W (p.Arg162Trp) variant details
- p.Arg162Trp
- rs768530577
- NCI-TCGA Cosmic COSV9977
- ExAC rs768530577
- TOPMed rs768530577
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.23
- CADD 24.50
- PolyPhen-2 0.85
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available