R105* (p.Arg105Ter) variant of CYP3A5 (Cytochrome P450 3A5)
R105* (p.Arg105Ter) in CYP3A5 (Cytochrome P450 3A5) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
R105* (p.Arg105Ter) variant details
- p.Arg105Ter
- rs776567184
- ExAC rs776567184
- gnomAD rs776567184
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.538
- CADD 34.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available