K59T (p.Lys59Thr) variant of CYP3A5 (Cytochrome P450 3A5)
K59T (p.Lys59Thr) in CYP3A5 (Cytochrome P450 3A5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
K59T (p.Lys59Thr) variant details
- p.Lys59Thr
- rs749438221
- ExAC rs749438221
- gnomAD rs749438221
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.21
- REVEL 0.09
- CADD 2.48
- PolyPhen-2 0.01
- SIFT 0.46
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available