K173R (p.Lys173Arg) variant of CYP3A5 (Cytochrome P450 3A5)
K173R (p.Lys173Arg) in CYP3A5 (Cytochrome P450 3A5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
K173R (p.Lys173Arg) variant details
- p.Lys173Arg
- ExAC rs764560819
- TOPMed rs764560819
- gnomAD rs764560819
- Missense
- Variant Prioritization Score for Impact Estimate 0.547
- REVEL 0.48
- CADD 25.10
- PolyPhen-2 0.99
- SIFT 0.02
- Most common in the HGDP:MBUTI population (allele frequency 0.083)
- Structural context available