K127R (p.Lys127Arg) variant of CYP3A5 (Cytochrome P450 3A5)
K127R (p.Lys127Arg) in CYP3A5 (Cytochrome P450 3A5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
K127R (p.Lys127Arg) variant details
- p.Lys127Arg
- TOPMed rs1255610231
- gnomAD rs1255610231
- Missense
- Variant Prioritization Score for Impact Estimate 0.363
- REVEL 0.19
- CADD 22.00
- PolyPhen-2 0.40
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available