I148M (p.Ile148Met) variant of CYP3A5 (Cytochrome P450 3A5)
I148M (p.Ile148Met) in CYP3A5 (Cytochrome P450 3A5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
I148M (p.Ile148Met) variant details
- p.Ile148Met
- TOPMed rs1303487578
- gnomAD rs1303487578
- Missense
- Variant Prioritization Score for Impact Estimate 0.424
- REVEL 0.28
- CADD 21.00
- PolyPhen-2 0.39
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.0011)
- Structural context available