G73R (p.Gly73Arg) variant of CYP3A5 (Cytochrome P450 3A5)
G73R (p.Gly73Arg) in CYP3A5 (Cytochrome P450 3A5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
G73R (p.Gly73Arg) variant details
- p.Gly73Arg
- NCI-TCGA TCGA novel
- ExAC rs781230602
- TOPMed rs781230602
- gnomAD rs781230602
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.436
- REVEL 0.30
- CADD 22.70
- PolyPhen-2 0.97
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available