G186A (p.Gly186Ala) variant of CYP3A5 (Cytochrome P450 3A5)
G186A (p.Gly186Ala) in CYP3A5 (Cytochrome P450 3A5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
G186A (p.Gly186Ala) variant details
- p.Gly186Ala
- rs962504304
- NCI-TCGA Cosmic COSV5611
- TOPMed rs962504304
- gnomAD rs962504304
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- REVEL 0.11
- CADD 16.30
- PolyPhen-2 0.01
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available