F33L (p.Phe33Leu) variant of CYP3A5 (Cytochrome P450 3A5)
F33L (p.Phe33Leu) in CYP3A5 (Cytochrome P450 3A5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
F33L (p.Phe33Leu) variant details
- p.Phe33Leu
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.189
- REVEL 0.08
- CADD 19.00
- PolyPhen-2 0.42
- SIFT 0.03
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 5e-05)
- Structural context available