F146L (p.Phe146Leu) variant of CYP3A5 (Cytochrome P450 3A5)
F146L (p.Phe146Leu) in CYP3A5 (Cytochrome P450 3A5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
F146L (p.Phe146Leu) variant details
- p.Phe146Leu
- gnomAD rs1237059482
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.14
- CADD 19.00
- PolyPhen-2 0.12
- SIFT 0.08
- Most common in the HGDP:MBUTI population (allele frequency 0.083)
- Structural context available