D174H (p.Asp174His) variant of CYP3A5 (Cytochrome P450 3A5)
D174H (p.Asp174His) in CYP3A5 (Cytochrome P450 3A5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
D174H (p.Asp174His) variant details
- p.Asp174His
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.26
- REVEL 0.22
- CADD 16.70
- PolyPhen-2 0.05
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available