G65R (p.Gly65Arg) variant of CYP2E1 (Cytochrome P450 2E1)
G65R (p.Gly65Arg) in CYP2E1 (Cytochrome P450 2E1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
G65R (p.Gly65Arg) variant details
- p.Gly65Arg
- gnomAD rs80297454
- cosmic curated COSV53312
- Missense
- Variant Prioritization Score for Impact Estimate 0.631
- REVEL 0.57
- MetaLR 0.66
- MetaSVM 0.50
- CADD 32.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available