R25W (p.Arg25Trp) variant of CYP2D6 (Cytochrome P450 2D6)
R25W (p.Arg25Trp) in CYP2D6 (Cytochrome P450 2D6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
R25W (p.Arg25Trp) variant details
- p.Arg25Trp
- cosmic curated COSV10063
- ExAC rs267608313
- TOPMed rs267608313
- gnomAD rs267608313
- Missense
- Variant Prioritization Score for Impact Estimate 0.385
- CADD 20.50
- PolyPhen-2 0.17
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available