Q27R (p.Gln27Arg) variant of CYP2D6 (Cytochrome P450 2D6)
Q27R (p.Gln27Arg) in CYP2D6 (Cytochrome P450 2D6) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
Q27R (p.Gln27Arg) variant details
- p.Gln27Arg
- rs1602590731
- ClinGen CA411775941
- ClinVar RCV001029559
- Ensembl rs1602590731
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.0872
- CADD 3.26
- PolyPhen-2 0.01
- SIFT 0.46
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available