P8L (p.Pro8Leu) variant of CYP2D6 (Cytochrome P450 2D6)
P8L (p.Pro8Leu) in CYP2D6 (Cytochrome P450 2D6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
P8L (p.Pro8Leu) variant details
- p.Pro8Leu
- TOPMed rs1275370019
- gnomAD rs1275370019
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- CADD 9.72
- PolyPhen-2 0.00
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available