P41L (p.Pro41Leu) variant of CYP2D6 (Cytochrome P450 2D6)
P41L (p.Pro41Leu) in CYP2D6 (Cytochrome P450 2D6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
P41L (p.Pro41Leu) variant details
- p.Pro41Leu
- 1000Genomes rs373243894
- ExAC rs373243894
- gnomAD rs373243894
- Missense
- Variant Prioritization Score for Impact Estimate 0.746
- CADD 25.10
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the 1KG:GIH population (allele frequency 0.0053)
- Structural context available