P35S (p.Pro35Ser) variant of CYP2D6 (Cytochrome P450 2D6)
P35S (p.Pro35Ser) in CYP2D6 (Cytochrome P450 2D6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data and structural context.
P35S (p.Pro35Ser) variant details
- p.Pro35Ser
- ExAC rs771774661
- TOPMed rs771774661
- gnomAD rs771774661
- Missense
- Variant Prioritization Score for Impact Estimate 0.737
- CADD 24.40
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available