P35L (p.Pro35Leu) variant of CYP2D6 (Cytochrome P450 2D6)
P35L (p.Pro35Leu) in CYP2D6 (Cytochrome P450 2D6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
P35L (p.Pro35Leu) variant details
- p.Pro35Leu
- gnomAD rs1258016506
- Missense
- Variant Prioritization Score for Impact Estimate 0.747
- CADD 25.70
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available