L18F (p.Leu18Phe) variant of CYP2D6 (Cytochrome P450 2D6)
L18F (p.Leu18Phe) in CYP2D6 (Cytochrome P450 2D6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data and structural context.
L18F (p.Leu18Phe) variant details
- p.Leu18Phe
- TOPMed rs1420797477
- gnomAD rs1420797477
- Missense
- Variant Prioritization Score for Impact Estimate 0.721
- CADD 22.80
- PolyPhen-2 0.56
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available