Y80C (p.Tyr80Cys) variant of CYP2C8 (Cytochrome P450 2C8)
Y80C (p.Tyr80Cys) in CYP2C8 (Cytochrome P450 2C8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
Y80C (p.Tyr80Cys) variant details
- p.Tyr80Cys
- NCI-TCGA Cosmic COSV1009
- cosmic curated COSV10098
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.404
- REVEL 0.31
- CADD 25.10
- PolyPhen-2 0.92
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available