V8M (p.Val8Met) variant of CYP2C8 (Cytochrome P450 2C8)
V8M (p.Val8Met) in CYP2C8 (Cytochrome P450 2C8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
V8M (p.Val8Met) variant details
- p.Val8Met
- NCI-TCGA TCGA novel
- ExAC rs778470178
- gnomAD rs778470178
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.125
- REVEL 0.11
- CADD 12.50
- PolyPhen-2 0.06
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available