V76L (p.Val76Leu) variant of CYP2C8 (Cytochrome P450 2C8)
V76L (p.Val76Leu) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
V76L (p.Val76Leu) variant details
- p.Val76Leu
- TOPMed rs1471056612
- Missense
- Variant Prioritization Score for Impact Estimate 0.538
- REVEL 0.51
- CADD 22.50
- PolyPhen-2 0.67
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 6e-05)
- Structural context available