S12Y (p.Ser12Tyr) variant of CYP2C8 (Cytochrome P450 2C8)
S12Y (p.Ser12Tyr) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
S12Y (p.Ser12Tyr) variant details
- p.Ser12Tyr
- ExAC rs756655248
- TOPMed rs756655248
- gnomAD rs756655248
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- REVEL 0.31
- CADD 22.30
- PolyPhen-2 0.65
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available