S115R (p.Ser115Arg) variant of CYP2C8 (Cytochrome P450 2C8)
S115R (p.Ser115Arg) in CYP2C8 (Cytochrome P450 2C8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
S115R (p.Ser115Arg) variant details
- p.Ser115Arg
- ESP rs369552457
- ExAC rs369552457
- TOPMed rs369552457
- gnomAD rs369552457
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.564
- REVEL 0.55
- CADD 22.80
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available