S115I (p.Ser115Ile) variant of CYP2C8 (Cytochrome P450 2C8)
S115I (p.Ser115Ile) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
S115I (p.Ser115Ile) variant details
- p.Ser115Ile
- ExAC rs755391351
- TOPMed rs755391351
- gnomAD rs755391351
- Missense
- Variant Prioritization Score for Impact Estimate 0.609
- REVEL 0.63
- CADD 22.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 0.00022)
- Structural context available