S114C (p.Ser114Cys) variant of CYP2C8 (Cytochrome P450 2C8)
S114C (p.Ser114Cys) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
S114C (p.Ser114Cys) variant details
- p.Ser114Cys
- ExAC rs752917521
- gnomAD rs752917521
- Missense
- Variant Prioritization Score for Impact Estimate 0.179
- REVEL 0.16
- CADD 18.20
- PolyPhen-2 0.89
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available