R125C (p.Arg125Cys) variant of CYP2C8 (Cytochrome P450 2C8)
R125C (p.Arg125Cys) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
R125C (p.Arg125Cys) variant details
- p.Arg125Cys
- 1000Genomes rs188111115
- Missense
- Variant Prioritization Score for Impact Estimate 0.367
- REVEL 0.20
- CADD 23.50
- PolyPhen-2 0.90
- SIFT 0.01
- Most common in the 1KG:YRI population (allele frequency 0.0043)
- Structural context available