R124W (p.Arg124Trp) variant of CYP2C8 (Cytochrome P450 2C8)
R124W (p.Arg124Trp) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
R124W (p.Arg124Trp) variant details
- p.Arg124Trp
- cosmic curated COSV64877
- ESP rs377386087
- ExAC rs377386087
- TOPMed rs377386087
- Missense
- Variant Prioritization Score for Impact Estimate 0.452
- REVEL 0.36
- CADD 21.90
- PolyPhen-2 0.96
- SIFT 0.01
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available