R105I (p.Arg105Ile) variant of CYP2C8 (Cytochrome P450 2C8)
R105I (p.Arg105Ile) in CYP2C8 (Cytochrome P450 2C8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
R105I (p.Arg105Ile) variant details
- p.Arg105Ile
- rs758378725
- NCI-TCGA Cosmic COSV6487
- cosmic curated COSV64876
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.259
- REVEL 0.15
- CADD 3.21
- PolyPhen-2 0.21
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available