L16F (p.Leu16Phe) variant of CYP2C8 (Cytochrome P450 2C8)
L16F (p.Leu16Phe) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L16F (p.Leu16Phe) variant details
- p.Leu16Phe
- TOPMed rs1188823438
- gnomAD rs1188823438
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.08
- CADD 4.57
- PolyPhen-2 0.01
- SIFT 0.35
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available