K59N (p.Lys59Asn) variant of CYP2C8 (Cytochrome P450 2C8)
K59N (p.Lys59Asn) in CYP2C8 (Cytochrome P450 2C8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes structural context.
K59N (p.Lys59Asn) variant details
- p.Lys59Asn
- rs1281247291
- NCI-TCGA Cosmic COSV6487
- Ensembl rs1281247291
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.435
- AlphaMissense 0.26
- MetaLR 0.34
- MetaSVM -0.42
- PolyPhen-2 0.46
- SIFT 0.01
- MutPred 0.49
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available