K118T (p.Lys118Thr) variant of CYP2C8 (Cytochrome P450 2C8)
K118T (p.Lys118Thr) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
K118T (p.Lys118Thr) variant details
- p.Lys118Thr
- TOPMed rs1011421475
- gnomAD rs1011421475
- Missense
- Variant Prioritization Score for Impact Estimate 0.211
- REVEL 0.04
- CADD 16.10
- PolyPhen-2 0.05
- SIFT 0.07
- Most common in the African/African-American population (allele frequency 4.9e-05)
- Structural context available