I74T (p.Ile74Thr) variant of CYP2C8 (Cytochrome P450 2C8)
I74T (p.Ile74Thr) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
I74T (p.Ile74Thr) variant details
- p.Ile74Thr
- TOPMed rs2033600096
- Missense
- Variant Prioritization Score for Impact Estimate 0.236
- REVEL 0.14
- CADD 5.75
- PolyPhen-2 0.01
- SIFT 1.00
- Most common in the REMAINING population (allele frequency 5e-05)
- Structural context available