I45K (p.Ile45Lys) variant of CYP2C8 (Cytochrome P450 2C8)
I45K (p.Ile45Lys) in CYP2C8 (Cytochrome P450 2C8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
I45K (p.Ile45Lys) variant details
- p.Ile45Lys
- gnomAD rs1252654584
- Missense
- Variant Prioritization Score for Impact Estimate 0.382
- REVEL 0.31
- CADD 20.40
- PolyPhen-2 0.30
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available