G109R (p.Gly109Arg) variant of CYP2C8 (Cytochrome P450 2C8)
G109R (p.Gly109Arg) in CYP2C8 (Cytochrome P450 2C8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
G109R (p.Gly109Arg) variant details
- p.Gly109Arg
- NCI-TCGA Cosmic COSV1009
- cosmic curated COSV10098
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.333
- REVEL 0.17
- CADD 20.40
- PolyPhen-2 0.55
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available