F65Y (p.Phe65Tyr) variant of CYP2C8 (Cytochrome P450 2C8)
F65Y (p.Phe65Tyr) in CYP2C8 (Cytochrome P450 2C8) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
F65Y (p.Phe65Tyr) variant details
- p.Phe65Tyr
- TOPMed rs903084051
- gnomAD rs903084051
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.351
- REVEL 0.27
- CADD 19.30
- PolyPhen-2 0.09
- SIFT 0.13
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available