W20R (p.Trp20Arg) variant of CYP2C19 (Cytochrome P450 2C19)
W20R (p.Trp20Arg) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
W20R (p.Trp20Arg) variant details
- p.Trp20Arg
- gnomAD 10-94762763-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.485
- REVEL 0.49
- MetaLR 0.38
- MetaSVM -0.39
- CADD 23.60
- PolyPhen-2 0.84
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.806
- Literature evidence available