W20* (p.Trp20Ter) variant of CYP2C19 (Cytochrome P450 2C19)
W20* (p.Trp20Ter) in CYP2C19 (Cytochrome P450 2C19) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
W20* (p.Trp20Ter) variant details
- p.Trp20Ter
- gnomAD 10-94762765-G-A
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.329
- CADD 35.00
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.806
- Literature evidence available