V8G (p.Val8Gly) variant of CYP2C19 (Cytochrome P450 2C19)
V8G (p.Val8Gly) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V8G (p.Val8Gly) variant details
- p.Val8Gly
- ExAC rs757485026
- gnomAD rs757485026
- Missense
- Variant Prioritization Score for Impact Estimate 0.206
- REVEL 0.05
- MetaLR 0.18
- MetaSVM -0.94
- CADD 10.40
- PolyPhen-2 0.16
- SIFT 0.11
- Most common in the South Asian population (allele frequency 0.00044)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.791